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Zarka, MH, Bridge, WJ 2017, Oral administration of -glutamylcysteine increases intracellular glutathione levels above homeostasis in a randomised human trial pilot study, Redox Biology , vol

Therefore, the System Xc GSHGPX4 axis constitutes a complete and finely tuned antioxidant defense chain ( via genetic knockout in various cell types, or directly targeting its active site with small molecule inhibitors like RSL3, consistently and efficiently induces typical ferroptosis (Wang L

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